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3D Cell Spheroid

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What is Cell Spheroid?

Cell spheroids mean the cells grown into a spherical mass by the 3D cell culture method. 3D cell culture refers to the improved methods that reproduce cell interactions with three- dimensional matrices in the clinical environment. In the clinical environment, cells exist in 3D microenvironments with intricate cell-cell and cell-matrix interactions. These interactions play a pivotal role in the normal activities of the cells. It was unable to reproduce the three-dimensional interactions in the traditional culture dish method. So, it is called ‘3D cell culture’ for various culture methods developed to improve this problem.

It is called ‘Cell spheroid’ for a spherical mass among various forms of cell masses grown in 3D cell culture. Spheroid is easy to form because it has the lowest energy among the three-dimensional shapes. And the cell masses produced spherically can faithfully reproduce key features of the three- dimensional environment. Recently, cell spheroid is the most widely used in 3D cell culture because of ease for implementation and high utilization relatively.

Application of Cell Spheroid

Anti-Cancer Drug Research: Cancer Spheroid can be used for an efficient anti-cancer drug development. It reproduces realistic tumor micro environment (TME), including hypoxia, stiffness, and cell signaling, with lower cost. Developers can expect anti-cancer drug candidate with higher success rate, using the cancer spheroid.
Cancer Disease Research: It is used to reproduce the features by the structure of cancer tissues. Cell spheroid is actively being implemented because cancer tissues have a characteristic change by volume.
Stem Cell Research: It is used for the aggregation stage in stem cell research. For the differentiation of stem cells, it is required the aggregation stage that a mass is formed and recognized in a specific size range. Cell spheroid is a very early stage for the aggregation.
Cell Therapy Research: It is applied to improve the efficacy of cell therapeutics. Cell Spheroid prevents the unnecessary spread of active ingredients and enables effective treatment.
Drug Delivery Research: It is used to study more effective drug delivery. Cell spheroid can be used as a model for the process to observe how the drug penetrates into the tissue and is delivered.

Features of Cell Spheroid

Mimic the Clinical Research Environment: Cell spheroid provides the research environment of the tissue or organ level. Typically, it has been conducted biological experiments at the cellular level. The cell study is limited by a low predictive power around 0.02% for the result of clinical tests, due to an environmental difference. Cell spheroid could provide a more realistic and similar environment with the clinical test by reproducing a stereoscopic environment and structure. It provides tissue or organ level research environment, beyond the cellular level. The results with cell spheroid are expected to expand the clinical applicability.
High Compatibility with Traditional Experiments: Cell spheroid not only provides an appropriate environment for 3D cell culture but also is highly compatible with the traditional two-dimensional experiment method. It enables us to conduct a higher level of experimentation without changing the environment and method of experiment. The experimentation with cell spheroid is employable for a high throughput system by supporting analysis based on microplates as well as applicable for the environment of traditional culture methods.